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The Infection is a disease that maddened Dr. Herbert Higginbotham and most of the other inmates at Eve's Asylum. It is made of meanie slime, some have the meanie eye decoration, but most cells including the infection found in the brain uses an orange evil creature eye similar to the Negativitron. Serious cases can be visually seen, with the infected person having swirling eyes and meanie horns protruding from their head. There are many types of the meanie infection cells most of them simply block parts of his body or shoot smaller meanies to stop the immune system from killing them. Some of the infection cells have arms legs and horns.

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